WOUND CARE CHALLENGES

As a major cause of delayed wound healing, biofilm triggers nonstop inflammation, which generates excess MMPs that degrade the ECM.1-5 Controlling the healing environment is even more of a challenge when patients are not able to be compliant.6,7

IMPROVING PATIENT LIVES STARTS WITH CHOOSING A SOLUTION THAT MEETS THEIR NEEDS

  • Many patients with lower-extremity chronic wounds are unable to change their own dressings6
  • Patients with chronic wounds fear touching their own wounds and prefer that their doctor or nurse exclusively control their care6,7
  • When treatments do force patients to change their own primary dressings, wounds can be exposed to bacteria in the home that can lead to contamination

Healthcare studies show that patient adherence improves when treatments require less intervention.8 PuraPly®AM and PuraPly®XT can help eliminate at-home primary dressing changes between patient treatments.9

BIOBURDEN & BIOFILM

  • Biofilm has been considered the most important single cause of persistent, delayed healing2
  • Biofilm triggers continuous immune-mediated inflammation in wounds1-3

Sharp debridement is essential but, alone, does not control microbial growth or prevent biofilm re-formation. It should be combined with a native ECM scaffold that provides broad-spectrum antimicrobial effectiveness within the product, managing bioburden and biofilm regrowth.2

BIOBURDEN BIOFILM

PROLONGED, ELEVATED INFLAMMATION

  • The prolonged inflammatory response to biofilm is ineffective and poorly orchestrated, causing damage to host tissues2
  • Increased neutrophils and macrophages accumulate, but fail to engulf, biofilm and secrete proteases, including MMPs2,4,5
BIOBURDEN BIOFILM

EXCESS MMPs

  • Persistent inflammation results in imbalance of excess proteases (eg, MMPs), decreased inhibitors (eg, TlMPs), and increased ROS4,5
  • Inflammatory protease levels may be 100 times higher in chronic vs acute wounds5,10
  • Excess and imbalanced MMPs break down ECM, degrade healing proteins, and prolong the inflammatory phase of healing3,5

However, a native ECM scaffold inhibits a wide range of MMPs, helping to address the proinflammatory proteolytic environment that stalls wounds.11

EXCESS MMPs

ECM DEGRADATION

  • ECM degradation prevents proper formation of the scaffold needed for cell migration and formation of granulation tissue12
  • Imbalance of ECM degradation and deposition perpetuates wound chronicity4

However, the cross-linked, native ECM scaffold of PuraPly AM and PuraPly XT resist ECM degradation in the wound.5,13

ECM=extracellular matrix;
MMPs=matrix metalloproteinases;
ROS=reactive oxygen species;
TIMPs=tissue inhibitors of metalloproteinases

ECM DEGRADATION

OVERCOME WOUND CARE CHALLENGES WITH PURAPLY® AM & PURAPLY®XT

Discover how PuraPly®AM and PuraPly®XT can help you take control of the healing environment, or contact an Organogenesis Tissue Regeneration Specialist to see how PuraPly AM can help your practice.

Contact us

Please refer to the PuraPly AM Instructions for Use and PuraPly XT Instructions for Use for complete prescribing information.

REFERENCES:

  1. Frykberg RG, et al. Adv Wound Care. 2015;4(9):560-582.
  2. Schultz G, et al. Wound Repair Regen. 2017;25(5):744-757.
  3. Gibson D, et al. Wounds Int. 2009;1(1):1-6.
  4. McCarty SM, et al. Adv Wound Care. 2013;2(8):438-447.
  5. Carpenter S, et al. Wounds. 2016;28(6 suppl):S1-S20.
  6. Fife C, et al. Wounds. 2007;19(10):255-257.
  7. Zulec M, et al. Int J Environ Res Public Health. 2019;16(4):e559.
  8. Atreja A, et al. MedGenMed. 2005;7(1):4-11.
  9. PuraPly Antimicrobial [package insert]. Canton, MA: Organogenesis Inc; 2020.
  10. Trengove NJ, et al. Wound Repair Regen. 1999;7(6):442-452.
  11. Negron I, et al. Int Wound J. 2014;11(4):392-397.
  12. Brett D. Wounds. 2008;20(12):347-356.
  13. Brantley J, et al. Wounds Int. 2016;7(3):1-5.