WOUND CARE CHALLENGES
Patient noncompliance, bioburden and biofilm, excess MMPs, and ECM degradation all present barriers to wounds healing correctly.
Inability and/or unwillingness to adhere to treatment plans for chronic wounds is a major barrier to healing.
- Many patients with lower-extremity chronic wounds are unable to change their own dressings1
- Patients with chronic wounds fear touching their own wounds and prefer that their doctor or nurse exclusively control their care1,2
- When treatments do force patients to change their own primary dressings, wounds can be exposed to bacteria in the home that can lead to contamination
BIOBURDEN & BIOFILM
- Acute and chronic wounds are susceptible to infection and biofilm development; as a result, early intervention to control bacterial bioburden is essential3
- Excessive bioburden and biofilm trigger a continuous inflammatory response and lead to increased proteases (eg, MMPs) that attack granulation tissue and stall wound healing4
- In healthy wound healing, proteases such as MMPs play a critical role by helping to remove damaged ECM and bacteria5,6
- In nonhealing wounds, the bacteria in biofilm generate excess and imbalanced MMPs that can5,6:
- Break down the ECM
- Degrade healing proteins
- Prolong the inflammatory phase of healing
- ECM serves as a structural scaffold for proteins and cell proliferation to support healing7
- ECM degradation prevents the formation of the scaffold needed for cell migration and prevents proper formation of the ECM and granulation tissue7
Please refer to the PuraPly AM Instructions for Use for complete prescribing information.
- Fife C, et al. Wounds. 2007;19(10):255-257.
- Zulec M, et al. Int J Environ Res Public Health. 2019;16(4):e559.
- Percival SL, et al. Adv Wound Care. 2015;4(7):389-397.
- Frykberg RG, et al. Adv Wound Care. 2015;4(9):560-582.
- Carpenter S, et al. Wounds. 2016;28(6 suppl):S1-S20.
- Gibson D, et al. Wounds Int. 2009;1(1):1-6.
- Brett D. Wounds. 2008;20(12):347-356.